Cooper5e_Ch17

The impact the establishment of embryonic stem cell

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Unformatted text preview: possibilities for the treatment of a variety of human diseases. Subsequent experiments demonstrated that embryonic stem cells could participate in normal mouse development following their injection into mouse embryos. Since gene transfer techniques could be used to introduce or mutate genes in cultured embryonic stem cells, these cells have been used to investigate the role of a variety of genes in mouse development. As discussed in Chapter 4, any gene of interest can be inactivated in embryonic stem cells by homologous recombination with a cloned DNA, and the role of that gene in mouse development can then be determined by introducing the altered embryonic stem cells into mouse embryos. In 1998 two groups of researchers developed the first lines of human embryonic stem cells. Because of the proliferative and differentiative capacity of these cells, they offer the hope of providing new therapies for the treatment of a variety of diseases. Although a number of technical problems and ethical concerns need to be addressed, transplantation therapies based on the use of embryonic stem cells...
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