These cells resembled normal embryo cells and could

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Unformatted text preview: inoma cells could also participate in normal development of a mouse if they were injected into early mouse embryos (blastocysts) that were then implanted into a foster mother. The ability of embryonal carcinoma cells to differentiate into a variety of (A) (B) cell types and to participate in normal mouse development suggested that these tumor-derived cells might be closely related to normal embryonic stem cells. However, the events that occurred during the establishment of teratocarcinomas in mice were unknown. Gail Martin hypothesized that the embryonal carcinoma cells found in teratocarcinomas were essentially normal embryo cells that proliferated abnormally simply because, when they were removed from the uterus and transplanted to an abnormal site, they did not receive the appropriate signals to induce normal differentiation. Based on this hypothesis, she attempted to culture cells from mouse embryos with the goal of isolating normal embryonic stem cell lines. Her experiments, together with similar work by Martin Evans and Matthew Kaufman (Establishment in culture of pluripotential cells from mouse e...
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This note was uploaded on 08/25/2009 for the course BIO 315 taught by Professor Steiner during the Spring '08 term at Kentucky.

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