They bind to members of the tnf receptor family which

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Unformatted text preview: variety of cell types. One of the best characterized members of this family is the cell surface receptor called Fas, which plays important roles in controlling cell death in the immune system. For example, apoptosis induced by activation of Fas is responsible for killing target cells of the immune system, such as cancer cells or virus-infected cells, as well as for eliminating excess lymphocytes at the end of an immune response. TNF and related family members consist of three identical polypeptide chains, and their binding induces receptor trimerization. The cytoplasmic This material cannot be copied, reproduced, manufactured, or disseminated in any form without express written permission from the publisher. © 2009 Sinauer Associates, Inc. Therapies based on a member of the TNF family are under clinical trial for the treatment of certain cancers. UNCORRECTED PAGE PROOFS 12 CHAPTER 17 FIGURE 17.12 Cell death receptors TNF and other cell death receptor ligands consist of three polypeptide chains, so their binding to cell death receptors induces receptor trimerization. Caspase-8 is recruited to the receptor and activated via interaction with adaptor...
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This note was uploaded on 08/25/2009 for the course BIO 315 taught by Professor Steiner during the Spring '08 term at Kentucky.

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