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Unformatted text preview: cannot be copied, reproduced, manufactured, or disseminated in any form without express written permission from the publisher. © 2009 Sinauer Associates, Inc. 7 UNCORRECTED PAGE PROOFS 8 CHAPTER 17 FIGURE 17.7 Regulatory interactions between Bcl-2 family members In normal cells, the BH3-only proapoptotic proteins are inactive, and the multidomain proapoptotic proteins are inhibited by interaction with antiapoptotic proteins. Cell death signals activate the BH3-only proteins, which then interact with the antiapoptotic proteins, leading to activation of the multidomain proapoptotic proteins and cell death. Apoptotic cell Normal cell BH3-only protein (inactive) Cell death signal Activation of BH3-only proapoptotic protein BH3-only protein (active) Antiapoptotic protein Multidomain proapoptotic protein Activation of multidomain proapoptotic protein Antiapoptotic protein Apoptosis IAPs were first discovered in virus-infected insect cells as viral proteins that inhibited apoptosis of the host cell. In mammalian cells, member...
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This note was uploaded on 08/25/2009 for the course BIO 315 taught by Professor Steiner during the Spring '08 term at Kentucky.

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