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© 2009 Sinauer Associates, Inc. 7 UNCORRECTED PAGE PROOFS
8 CHAPTER 17 FIGURE 17.7 Regulatory
interactions between Bcl-2 family
members In normal cells, the
BH3-only proapoptotic proteins are
inactive, and the multidomain
proapoptotic proteins are inhibited
by interaction with antiapoptotic proteins. Cell death signals activate the
BH3-only proteins, which then interact
with the antiapoptotic proteins, leading to activation of the multidomain
proapoptotic proteins and cell death. Apoptotic cell Normal cell
(inactive) Cell death signal
Activation of BH3-only
proapoptotic protein BH3-only protein
protein Activation of
protein Apoptosis IAPs were first discovered in
virus-infected insect cells as viral
proteins that inhibited apoptosis
of the host cell. In mammalian cells, member...
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