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arrest and apoptosis in response to DNA damage. Whether DNA damage in
a given cell leads to apoptosis or reversible cell cycle arrest may depend on
the extent of damage and the resulting level of p53 induction, as well as the
influence of other life/death signals being received by the cell.
Growth factor deprivation is another form of cell stress that activates the
intrinsic pathway of apoptosis. In this case, apoptosis is controlled by signaling pathways that promote cell survival by inhibiting apoptosis in This material cannot be copied, reproduced, manufactured, or disseminated in any
form without express written permission from the publisher.
© 2009 Sinauer Associates, Inc. Bax Cytochrome c Apaf-1 Apoptosome Caspase-9 Pro-caspase-3 Active caspase-3 Apoptosis UNCORRECTED PAGE PROOFS
10 CHAPTER 17 Figure 17.9 Regulation of caspases by IAPs in Drosophila Both initiator and
effector caspases are inhibited by IAPs. Many signals that induce apoptosis in
Drosophila function by activating members of a family of proteins (Reaper, Hid,
and Grim) that inhibit the IAPs, resulting in caspase activation. Death
signal Reaper, Hid,
Grim IAPs Initiat...
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