Thus p53 mediates both cell cycle arrest and

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Unformatted text preview: e arrest and apoptosis in response to DNA damage. Whether DNA damage in a given cell leads to apoptosis or reversible cell cycle arrest may depend on the extent of damage and the resulting level of p53 induction, as well as the influence of other life/death signals being received by the cell. Growth factor deprivation is another form of cell stress that activates the intrinsic pathway of apoptosis. In this case, apoptosis is controlled by signaling pathways that promote cell survival by inhibiting apoptosis in This material cannot be copied, reproduced, manufactured, or disseminated in any form without express written permission from the publisher. © 2009 Sinauer Associates, Inc. Bax Cytochrome c Apaf-1 Apoptosome Caspase-9 Pro-caspase-3 Active caspase-3 Apoptosis UNCORRECTED PAGE PROOFS 10 CHAPTER 17 Figure 17.9 Regulation of caspases by IAPs in Drosophila Both initiator and effector caspases are inhibited by IAPs. Many signals that induce apoptosis in Drosophila function by activating members of a family of proteins (Reaper, Hid, and Grim) that inhibit the IAPs, resulting in caspase activation. Death signal Reaper, Hid, Grim IAPs Initiat...
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This note was uploaded on 08/25/2009 for the course BIO 315 taught by Professor Steiner during the Spring '08 term at Kentucky.

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