Cooper5e_Ch17

Uncorrected page proofs cell death and cell renewal

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Unformatted text preview: nc. UNCORRECTED PAGE PROOFS CELL DEATH AND CELL RENEWAL KEY the ced-9 gene (which was subsequently identified by Horvitz and colleagues), proved to be prototypes of the central regulators and effectors of apoptosis that are highly conserved in evolution. The cloning and sequencing of ced-3 revealed that it was related to a protease that had been previously identified in mammalian cells, and which became the first member of the caspase family. The C. elegans ced-9 5 EXPERIMENT gene was related to the bcl-2 oncogene, first isolated from a human B cell lymphoma, which had the unusual property of inhibiting apoptosis rather than stimulating cell proliferation. And ced-4 was found to encode an adaptor protein related to mammalian Apaf-1, which is required for caspase activation. The identification of these genes in C. elegans thus led the way to understanding the molecular basis of apoptosis, with broad implications both for development and for the maintenance of normal adult tissues. Since abnormalities of apoptosis contribute to a wide variety of diseases, including cancer, autoimmune disease, and neurodegenerative disorders, the seminal findings of Ellis and Horvitz have impacted a wide range of areas in biology and medicine. tio...
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This note was uploaded on 08/25/2009 for the course BIO 315 taught by Professor Steiner during the Spring '08 term at Kentucky.

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