extracellular

extracellular - ANAT3231 - Cell Biology Lecture 8 School of...

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ANAT3231 - Cell Biology Lecture 8 School of Medical Sciences The University of New South Wales Dr Mark Hill Cell Biology Laboratory Room G20 Wallace Wurth Building Email: m.hill@unsw .edu.au Extracellular Matrix © Dr M.A. Hill 2004 Slide 1
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UNSW Copyright Notice COMMONWEALTH OF AUSTRALIA Copyright Regulations 1969 WARNING This material has been copied and communicated to you by or on behalf of the University of New South Wales pursuant to Part VB of the Copyright Act 1968 ( the Act ). The material in this communication may be subject to copyright under the Act. Any further copying or communication of this material by you may be the subject of copyright protection under the Act. Do not remove this notice. © Dr M. A. Hill, 2004 Cell Biology Laboratory School of Medical Sciences, Faculty of Medicine The University of New South Wales, Sydney, Australia Web: http://anatomy.med.unsw.edu.au/cbl/cbl.htm Email: m.hill@unsw.edu.au Extracellular Matrix © Dr M.A. Hill 2004 Slide 2
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Extracellular Matrix (ECM) Essential Cell Biology Ch19 p594-604 Molecular Biology of the Cell p971-1009 Animal and Plant ECM – Material secreted and deposited by cells ANAT3231 Lecture 8 Extracellular matrix http://cellbiology.med.unsw.edu.au/units/science/lecture08.htm Extracellular Matrix © Dr M.A. Hill 2004 Slide 3
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Cell-cell, Cell-Matrix Adhesions From: Molecular Cell Biology Extracellular Matrix © Dr M.A. Hill 2004 Slide 4
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ECM Function Support for cells Pattern of ECM regulates Polarity cell division adhesion motility Development migration differentiation Growth factors Image: MBoC ch19f28.gif Extracellular Matrix © Dr M.A. Hill 2004 Slide 5
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ECM Structure- Glycoproteins • Collagen – main fibers • Proteoglycans – high carbohydrate • Other Glycoproteins – Laminin – Fibronectin Image: MBoC ch19f31.gif Extracellular Matrix © Dr M.A. Hill 2004 Slide 6
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Shapes and Sizes ECM molecules Protein- green Glycosaminoglycan in- red Extracellular Matrix © Dr M.A. Hill 2004 Slide 7 Image: MBoC ch19f57.gif
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Collagen tensile strength and elasticity Tendons Cartilage Bone half total body proteins (by weight) Extracellular Matrix © Dr M.A. Hill 2004 Slide 8
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Collagen Components • Insoluble glycoprotein – protein + carbohydrate Protein high glycine and 2 modified amino acids hydroxylysine hydroxyproline (gly-X-Y)n Carbohydrate glucose galactose Extracellular Matrix © Dr M.A. Hill 2004 Slide 9
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Collagen Structure Extracellular Matrix © Dr M.A. Hill 2004 Slide 10
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Collagen Protein • 3 polypeptide (a) chains left hand helix, forms fibers 14 different (vertebrate) collagens by different combinations of a-chains numbered I - XIV I, II, III main fibers, flexible I bone, skin, tendons 90% of all collagen II cartilage Extracellular Matrix © Dr M.A. Hill 2004 Slide 11
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Collagen Fibers Type I, II, III cross striated showing overlapping packing of individual collagen
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extracellular - ANAT3231 - Cell Biology Lecture 8 School of...

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