Lecture #7v2 (2)

Lecture #7v2 (2) - INTERACTIONS BETWEEN CELLS AND THEIR...

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INTERACTIONS BETWEEN CELLS ND THEIR ENVIRONMENT AND THEIR ENVIRONMENT
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Interactions Between Cells and Their Environment Cell-Cell Interactions elium epith e ve tissu onnecti v Fig. 7.1- Skin Tissue Extracellular Matrix co
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The extracellular ace - imal space animal cells are sugar coated with the oligosaccharides of surface lipids and proteins. The sugar coating is ferred to as the referred to as the glycocalyx. Electron micrograph of the apical surface of an epithelial cell from the lining of the intestine, showing the glycocalyx, which has been stained with the iron-containing protein ferritin.
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The extracellular matrix (ECM) an organized network of extracellular materials that is present beyond the immediate vicinity of the plasma membrane. Fixed Red blood cells Thickness of extracellular matrix ne of the best- efined tracelluar atrices is the asement membrane ( so called basal One of the best defined extracelluar matrices is the basement membrane ( also called basal lamina), a continuous sheet 50 to 200 nm thick that 1) surrounds muscle and fat cells 2) underlies the basal surface of epithelial tissues (skin, digestive lining, respiratory cell lining) 3) underlies the inner endothelial lining of blood vessels.
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Extracellular Matrix Organized network of extracellular materials outside plasma embrane provides support and determines shape and membrane, provides support and determines shape and activity of cell Fig. 7.5 he proteins depicted ( bronectin collagen, and minin contain binding sites for one another The proteins depicted (fibronectin, collagen, and laminin) contain binding sites for one another as well as binding sites for the receptors (integrins) that are located at the cell surface. The proteoglycans are huge protein-polysaccharide complexes that occupy much of the volume of the extracellular space.
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Collagen- collagen comprise a family of fibrous glycoproteins that are present only in extracellular glycoproteins that are present only in tl l l t i C l l f d t h h t t hi l extracellular matrices. Collagen are found throughout the animal kingdom and are noted for their high tensile strength, that is, their resistance to pulling forces.
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Extracellular Matrix Components not aligned in register- Comprised of linear repeating modules organized into fibrous filament or network strength ewo Collagen ibrous lycoprotein ber - Fibrous glycoprotein - High tensile strength (stretches without breaking) - roduced primarily by fibroblasts bril fiber Lys Defective in Scurvy (Vit C def) Produced primarily by fibroblasts in connective tissues, smooth muscle, and epithelial cells - Triple helix of α chains- >20 Types fibril Fig. 7.6 α chain
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This note was uploaded on 08/25/2009 for the course BIO 315 taught by Professor Steiner during the Spring '08 term at Kentucky.

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Lecture #7v2 (2) - INTERACTIONS BETWEEN CELLS AND THEIR...

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