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Lecture #8v2 (2)

Lecture #8v2 (2) - Extracellular Matrix Components...

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2/23/2009 1 Extracellular Matrix Components Comprised of linear repeating modules organized into fibrous filament or network Collagen not aligned in register- strength - Fibrous glycoprotein - High tensile strength (stretches without breaking) - Produced primarily by fibroblasts in connective tissues, smooth muscle, and epithelial cells fibril fiber Lys Defective in Scurvy (Vit C def) Fig. 7.6 - Triple helix of α chains- >20 Types Gly-Pro-X repeat α chain - Types I, II, III, and IV- fibrillar diseases of hyperflexible joints, fragile bones, dwarfism, etc. - Type IV- nonfibrillar, sheet forming (cornea) non- α chain segments and globular ends allow assembly into lattice instead of filament
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