Major Histocompatibility - MHC

Major Histocompatibility - MHC - Major Histocompatibility -...

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Major Histocompatibility - MHC BIO/MI494G Oct. 6,2008 Dr. Joe McGillis MN380 323-6721 jpmcgi01@uky.edu I. Overview 1. TCR-MHC binding complex 2. Discovery of MHC a. George Snell and inbred mice b. IRG's II. Nomenclature & MHC Structure Human HLA system nomenclature 2. MHC structure 3. Regulation of MHC expression III. MHC Gene Complex IV. Why MHC polymorphism? 1. Protection of the Species a. Natural Selection New MHC variants
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MHC - Bare Facts and Nomenclature MHC Gene Families (chr 16) Class I Class II Cell Expression most cells APCs Dendritic Cells Macrophages B-Cells Other: endothelial cells, microglia T cell recognition CD8 CD4 Terms: Polymorphic, oligomorphic, monomorphic, isotypeslisoforms, alleles/allotypes, syngeneic,
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This document was uploaded on 08/25/2009.

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Major Histocompatibility - MHC - Major Histocompatibility -...

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