Transplantation Immunology

Transplantation Immunology - BIO/MI 494G Transplantation...

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Unformatted text preview: BIO/MI 494G Transplantation Immunology Fall, 2008 I. Introduction II. Different types of transplants 1. Autograft 2. Isograft 3. Allograft 4. Xenograft III. Allograft reaction 1. First set reaction 2. Second set reaction 3. Immunologic mechanism IV. Mechanisms involved allograft rejection 1. Role of CD4 and CD8 T-cells 2. Matching donor and recipient at MHC 3. Presentation of alloantigens on the transplant to recipients T- cells a. direct recognition b. indirect organization 4. Effector mechanisms in allograft rejection V. Clinical manifestations of allograft rejection 1. Introduction 2. Hyperacute rejection 3. Acute rejection 4. Chronic rejection Genetic barriers to transplantation isograft autograft between from one part genetically of lhe body identical to another individuals e.g. trunk e.g. to arm monozygotic twins, or within an inbred strain allograft xenograft between between different members of members different of the same species species e,g. monkey e.g. Mr Smith to man to Mr Jones Fig. 27.2 The genetic relationship between the donor and recipient determines whether or not rejection will occur. Autografts or isografts are usually accepted. while allografts and xenograhs are not. Skin graft I First set rejection I I Second set rejection I Yes I Second set rejection I Figure 16-1 First and second set allograft rejection. Results of the experiments shown indicate that grah rejection displays the features of adaptive immune responses, namely, memory and mediation by lymphocytes. A strain B mouse will reject a grah from a strain A mouse with fHSI set kinetiCS (Ieh panel', A strain B mouse sensitized by a previous grah from a strain A, mouse will reject a second grah from a strain A mouse wilh second set kinetics (middle panel), demonstrating memory. A strain B mouse injected with lymphocytes from another stram B mOilse lhal has rejected a grah from a wain A mouse will relect a gran from a strain A mouse with second set kinctics (right panel!. demonwating lhe .ole 01 lymphocytes in medialing .ejecrion and memory. A SHain B mouse sens'i1l1ed by a prevIous grah hom a slrain A mouse wdl rejecl a grah hom a third umelaled sltain wllh f,rSI sel kinel Cs. thus demonsUatlng another feature 01 adapl Ve immunItY. specificity (nOl shown!. Syngeneic grahs are never rejecled lnOI shownl. Direct aliorecognlUon IndIrect allorecognttlon B Indirect alloantigen presentation T cell specific for Allogeneic Professional polymorphic peptide from MHC V;PC in recipient allogeneic MHC molecule f ~r+ Presentation of ! 1-" . ~ : .. processed peptide '. R!fJ t> .. of allogeneic . . MHC molecule bound i SellMHC to self-MHC molecule Peptide containing Uptake and processing of polymorphic sequence of allogeneic MHC molecules allogeneic MHC molecule by recipient APC Direct alloantigen presentation Allogeneic MHC Alloreaclive T cell ~CifiC forinlacl ~0'~' ""emo","" Direct presentation of allogeneic MHC molecule by APC in graft Figure 12.19 Direct and Indi..ect paUlwa)'s of allorecognitlon...
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Transplantation Immunology - BIO/MI 494G Transplantation...

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