CellsandOrgansoftheImmuneSystem

CellsandOrgansoftheImmuneSystem - BIO/MI494G Fall 2008...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
BIO/MI494G Fall 2008 Cells and Organs of the Immune System I. Definition of terms 1. Immune 2. Immunity 3. Immune response 4. Immunology a. Antigen (immunogen) b. Antibody c. Leukocytes (white cells) 5. Vaccination (immunization) 6. Vaccines 7. Operational definition of immunology II. Cardinal features of adaptive immune responses 1. Specificity 2. Diversity 3. Memory 4. Clonal expansion 5. Specialization 6. Contraction and homeostatis 7. Discrimination of self from non-self III. Types of immunity 1. Natural (innate. non-adaptive) a. Cells b. Soluble factors c. Physical barriers 2. Acquired (Specific) a. Humoral immunity b. Cell-mediated immunity IV. Lymphoid organs and cells 1. Primary lymphoid organs a. Bone Marrow b. Thymus 2. Secondary lymphoid organs a. Lymph nodes b. Spleen c. Mucosal associated 3. Cells of the immune system a. Lymphocytes (T and B-cells) b. Macrophages/monocytes c. Polymorphonuclear leukocytes (granulocytes) i. Neutrophil ii. Basophil iii. Eosinophil d. Mast cells
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
V. Origin of T, B-cells and other hematopoetic cells 1. Stem cells 2. Acquisition of immunocompetency a. Thymus dependent (T-cells) b. Bone marrow dependent (B-cells) 3. Myeloid progenitor a. Polymorphonuclear leukocytes (basop~il, neutrophil and eosinophil) b. Monocyte and machrophage c. Dendritic cells d. Mast cell 4. Erythroid progenitor a. Erythroid progenitor b. Platelet VI. Function of cells involved in immune response 1. B-cells - antibody production a. B-cells receptor (BCR) 2. T-cells - effector/inducer a. T-cell receptor (TCR) b. T-helper (TH1 and TH2) c. T-cytotoxic (Tc) d. T-regulatory (T reg) e. Natural killer (NK) cell 3. Monocytes/macrophage a. Antigen processing and presentation b. Non specific effector function 4. Cytokine production a. Lymphokines b. Chemokines 5. Immune response protects against four classes of pathogens 6. Lymphocyte trafficking VII. Example of antibody response 1. Immunization 2. Interaction of antibody with antigen a. Antigenic specificity 3. Immunologic memory VIII. Example of cell-mediated immune response 1. Immunization 2. T-cells (TH1 and Tc) 3. Cytokines a. Affects on macrophages, T-cells and other cells 4. Role of macrophages IX. Clonal selection theory
Background image of page 2
-------- Table 1-1. Effectiveness of Vaccines for Some Common Infectious Diseases Disease Maximum number of cases (year) Number of cases in 2004 Percent change Diphtheria 206,939 (1921) 0 -99.99 Measles 894,134 (1941) 37 -99.99 Mumps 152,209 (1968) 236 -99.90 Pertussis 265,269 (1934) 18,957 -96.84 Polio (paralytic) 21,269 (1952) 0 -100.0 Rubella 57,686 (1969) 12 -99.98 Tetanus 1,560 (1923) 26 -98.33 Haemophilus influenzae type B -20,000 (1984) 16 -99.92 Hepatitis B 26,611 (1985) 6,632 -75.08 This table illustrates the striking decrease in the incidence of selected infectious diseases for which effective vaccines have been developed. Adapted from Orenstein WA, AR Hinman, KJ Bart, and SC Hadler. Immunization. In
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

Page1 / 13

CellsandOrgansoftheImmuneSystem - BIO/MI494G Fall 2008...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online