Immunoglobulin Rearrangement and B Cell Maturation I, II, & III

Immunoglobulin Rearrangement and B Cell Maturation I, II, & III

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COMPLEMENT Immunobiology, BIO/MI 494G Dr. Joe McGillis Sept. 22,24 MN-380/MN-375 323-6721 jpmcgiO 1@uky.edu Reading: Chapter 7, pp. 205-222 I. Nomenclature and Overview V. Complement Regulatory Proteins - Regulators of Complement Activation Discovery - Jules Bordet Functions A. RCA Structure Zymogen Complement control protein domains Pathways B. CRP's in Plasma II. Classical Pathway of Complement Activation Cl Inhibitor C4 Binding Protein/Factor I C1 Factor H/Factor I C3 Convertase (C4, C2) C3 C. Cell Membrane CRP's C5 Convertase Membrane Attack Complex (C5, C6, DAF C7, C8, C9) MCP CR1 III. Complement Functions D. Membrane Attack Complex Inhibitors A. Opsonization Complement Receptors 1. Soluble (S protein, clusterin, factor J) CR1 and CR2 2. Cell Surface (HRF, CD59) CR3 and CR4 B. Inflammation - Anaphylatoxins C. Immune Complex Removal IV. Other Pathways of Complement Activation A. MB-Lectin Pathway B. Alternative Pathway
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I . ,>. CLASSICAL Ii' M,B.lEC~~ PATHWAY P~THW,~ JIl. . I .. Antigen:antibody ,.,~ Lep;tin' bin~ing to ~ complexes '. pat~ogen (urfaces II I I 1) -:J [,.' ,-. ." I "C6mple~_ent aq,~.v~tion I I J~ ~ ~ ~\ ~If LTfRf.rJTIV ni!S ~:~ rP THWAYJ,; -~ :.~ -l: Ii Palh,o.gen surlac,es i " v Recruitment of inflammatory cells v Opsonization of pathogens V Killing of pathogens ~ .',' _->'"" , .v·· " figure 2·18 Immunobiology, 6/e. (4) Garland Science 2005) C1q figure 2·21 Immunobiology, 6/e. (~Garland Science 2005)
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Immunoglobulin Rearrangement and B Cell Maturation I, II, & III

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