0825 - Desired blood glucose level Insulin Insulin-release...

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BME-511 Week 1
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1. PCS are built for versatility and are multifunctional 2. PCS contain components whose properties are unknown and have to be identified. 3. No explicit comparator (feedback is embedded) - no “reference” setpoint 4. Nonlinearities are pervasive in PCS
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5. Cross-coupling or interaction across multiple control systems
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6. Adaptive nature of physiological control systems
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Nonlinearities are pervasive in Physiological Control Systems Nonlinear Phenomenon: Phase Resetting
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“Artificial” Control System
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Example of Artificial Control System: “ARTIFICIAL PANCREAS” (for Type 1 Diabetes) A: Insulin Pump w/ refillable vial : Insulin delivery tube B: Insulin delivery tube C: Continuous glucose sensor D: Wireless transmitter
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losed op blood glucose control Closed-loop blood glucose control
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Unformatted text preview: Desired blood glucose level Insulin Insulin-release Glucose Glucose sensor Measured blood glucose Questions to be answered : 1. Dynamics of the system open-loop control vs closed-loop control; different parameters: (a) time-domain (b) frequency-domain 2. Stability of the system open-loop control vs closed-loop control 3. What are the properties of the system being controlled? - system identification (parameter estimation) pen op Gain = G Open-loop Gain = G c G p Closed-loop Gain = G c G p 1 + G c G p LG H OLG OLG CLG + = 1 OLG CLG < Degree to which feedback reduces the effect of disturbances ~ G G H p c G p G c H = Loop Gain (LG) Determination of steady state operating (equilibrium) point a c e f G f = e M f G L L = L G f s a = L = L- G M f e...
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0825 - Desired blood glucose level Insulin Insulin-release...

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