Hodgkin-Huxley 1952

Hodgkin-Huxley 1952 - 1952;117;500-544 J. Physiol. A. L....

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Unformatted text preview: 1952;117;500-544 J. Physiol. A. L. Hodgkin and A. F. Huxley nerve and its application to conduction and excitation in A quantitative description of membrane current JournalsRights@oxon.blackwellpublishing.com reproduced without the permission of Blackwell Publishing: months after publication. No part of this article may be articles are free 12 The Journal of Physiology Online . http://jp.physoc.org/subscriptions/ go to: Physiology Online The Journal of continuously since 1878. To subscribe to The Physiological Society. It has been published is the official journal of The Journal of Physiology Online 2008 This information is current as of September 12, article is open access. public website for 12 months after publication unless This version of the article may not be posted on a http://jp.physoc.org available at: This is the final published version of this article; it is JournalsRights@oxon.blackwellpublishing.com reproduced without the permission of Blackwell Publishing: months after publication. No part of this article may be articles are free 12 The Journal of Physiology Online . http://jp.physoc.org/subscriptions/ go to: Physiology Online The Journal of continuously since 1878. To subscribe to The Physiological Society. It has been published is the official journal of The Journal of Physiology Online 500 J.Physiol. (I952) II7, 500-544 A QUANTITATIVE DESCRIPTION OF M E M B R A N E CURRENT AND ITS APPLICATION TO CONDUCTION AND EXCITATION IN NERVE BY A. L. HODGKIN AND A. F. HUXLEY FromthePhysiologicalLaboratory, University of Cambridge (Received10March 1952) Thisarticleconcludesa seriesofpapers concernedwith the flowofelectric current through the surface membrane of a giant nerve fibre (Hodgkin, Huxley & Katz, 1952; Hodgkin & Huxley, 1952 a-c). Its generalobject isto discu the results of the preceding papers (Part I), to put them into mathematical form (PartII) and to show that they will account forcon- ductionandexcitationinquantitativeterms (Part III). PART I. DISCUSSION OF EXPERIMENTAL RESULTS The results described in the preceding papers suggest that the electrical behaviour ofthe membrane may be representedby the network shown in Fig.1. Current can becarriedthroughthemembrane eitherbychargingthe membranecapacityorbymovementofion-s through theresistancesin parallel withthecapacity. The ioniccurrent isdividedintocomponents carried by sodium and potassiumions(INaand IK), anda small 'leakage current' (I,) madeup bychloride andotherions. Eachcomponentoftheioniccurrentis determined bya driving forcewhich may convenientlybe measuredas an electricalpotential difference and a permeability coefficientwhich has the dimensionsofa conductance. Thusthesodiumcurrent (INa) isequaltothe sodiumconductance (9Na) multipliedbythedifferencebetweenthemembrane potential(E)andtheequilibriumpotentialforthesodiumion (ENa). Similar equations applyto 'K and I, andarecollectedonp.505....
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Hodgkin-Huxley 1952 - 1952;117;500-544 J. Physiol. A. L....

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