lec 4 - Introductory Pharmacology Chemical properties of...

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Unformatted text preview: Introductory Pharmacology Chemical properties of Relevance to Pharmacology Lecture 4: April 6, 2009 Introduction to Bioassays, Dose response and Quantitative Analysis of Drug Responses Receptor Quantitative Kinetics / Equilibrium Binding Effects of Competitive and Noncompetitive Antagonists Receptor Modulation Chemical and physicochemical properties of drugs or chemicals determining drug / chemical efficacy or toxicity exerting an action (f) type of interaction with target sites irreversible: covalent bonding reversible: ionic interaction, hydrophobic interaction, hydrogen bond formation, van der Waals interactions (g) stereochemistry selectivity of fit: defines the receptor construct of pharmacology, may be important in binding to enzymes From prior lecture slide set Chemical and physicochemical properties of drugs or chemicals determining drug / chemical efficacy or toxicity getting to & exerting an action ( h) molecular stability stability to local environment often determines route of drug administration, example acid labile drugs like peptides (i) molecular reactivity does it have sites that are highly reactive (j) must it undergo chemical reaction to form the active substance (e.g., prodrugs) acetaminophen (Tylenol) the product of hepatic metabolism of phenacetin From prior lecture slide set Relating chemical and physicochemical properties of...
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lec 4 - Introductory Pharmacology Chemical properties of...

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