lecture33_1

lecture33_1 - Most environmental causes of cancer are...

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Most environmental causes of cancer are mutagens: mutagenic compounds, X-rays, uv Enzymatic conversion ve epoxide Spontaneous reaction with N7 of guanosine i H 3 C O O O O O O to react H 3 C O O Aflatoxin B O O HO O O N + HN G H 2 N N 3,4-benzpyrene N DNA
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Cancer tends to arise in actively dividing cells • Epithelial cells (lining of intestine, lungs etc.) = carcinoma • Blood and lymphatic cells = lukemia, meyloma, lymphoma • Connective tissue (bones, tendons muscle) = sarcoma
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Cancer is a genetic disease of somatic cells The underlying cause is mutations that release cells from the normal constraints that exist in well organized tissues allowing uncontrolled growth Which are the key genes that are mutated ?
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Incidence of stomach cancer as a function of age 0 100 200 300 400 500 600 700 800 0 5 10 30 20 25 15 35 55 45 50 40 60 80 85 70 75 65 Age (1992) Stomach Cancer Rate per 100,000 Females Females (1975) Males (1992) Males (1975) Incidence of stomach cancer as a function of age.
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This note was uploaded on 09/03/2009 for the course BIOL 7.03 taught by Professor Chriskaiser during the Fall '04 term at MIT.

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lecture33_1 - Most environmental causes of cancer are...

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