lecture33_3

lecture33_3 - 0 G 2 Formation of spindle and alingment of...

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Wild type cdc28 mutant cdc7 mutant Images removed due to copyright reasons.
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What is the basic organization of the cell cycle ? Are the steps of the cycle mechanistically linked ? "substrate-product" model Is there an autonomous "cell cycle clock" ?
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Opposite effects of cdc2 alleles in S. pombe cdc2 + (wild type) - cdc2 (recessive) cdc2 D (dominant) Figure by MIT OCW.
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There is there an autonomous "cell cycle clock" which is composed of cyclin + CDK The amount of cyclins oscillates throughout the cell cycle However, the steps of the cycle are linked by negative feedback loops known as "checkpoint control" pathways
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growth (DNA synthesis) S G 1 G
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Unformatted text preview: 0 G 2 Formation of spindle and alingment of chromosomes Completion of DNA synthesis Repair of DNA damage Extracellular control signals Daughter cells M (Mitosis) Checkpoint control pathways Figure by MIT OCW. Image removed due to copyright reasons. General types of oncogenic mutations Activation of growth control pathways signaling quiescent cells to divide inappropriately Inactivation of checkpoints allowing cells with damaged DNA or misaligned chromosomes to divide allowing high mutation rates and chromosome imbalances Inactivation of DNA repair genes allowing high mutation rates causing other oncogenic mutations...
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lecture33_3 - 0 G 2 Formation of spindle and alingment of...

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