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lecture34 - Genetics of Cancer Lecture 34 Alterations in...

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Genetics of Cancer Lecture 34
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Alterations in different kinds of Genes cause Cancer Oncogenes dominant gain-of-function mutations promote cell transformation Tumor suppressor genes recessive, loss-of-function mutations promote cell transformation Mutator genes Usually recessive, loss-of-function mutations that increase spontaneous and environmentally induced mutation rates
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Most of the mutations that contribute to cancer occur in somatic cells – but germ line mutations can also contribute egg sperm zygote endoderm colon growth and differentiation mitotic divisions mitotic divisions 2 meiotic divisions gametes (eggs or sperm)
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Most of the mutations that contribute to cancer occur in somatic cells – but germ line mutations can also contribute egg sperm zygote endoderm colon growth and differentiation mitotic divisions mitotic divisions 2 meiotic divisions gametes (eggs or sperm) germ line
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Cytoplasmic signal transduction proteins Nuclear proteins Growth Factor Genes Signal Transduction and Growth Regulation
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Cytoplasmic signal transduction proteins Nuclear proteins Growth Factor Genes Great Targets for Dominant Acting Oncogenes Secreted Growth factors, e.g. EGF, PDGF Specific Receptors for Growth factors e.g., RET, EGFR G-proteins, kinases and their targets e.g., RAS, ABL, (RB) Transcription factors, e.g., MYC, JUN, FOS
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Receptor Tyrosine Kinases (RTKs) Extracellular domain Cytoplasmic domain Exterior Cytoplasm Kinase active site Transmembrane domain Figure by MIT OCW.
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Receptor Tyrosine Kinases (RTKs) Images removed due to copyright reasons.
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