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4-21 transgenes in mammals

4-21 transgenes in mammals - TRANSGENES I N MA M MALS KLUG...

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TRANSGENES IN MAMMALS KLUG pg. 543-544 & reading provided 21.5 Geneticists Advance Our Understanding of Molecular Processes by Undertaking Genetic Research in Model Organisms: Three Case Studies The Mouse: A Model for ALS Gene Therapy -amyotrophic lateral sclerosis (ALS): incurable neurodegenerative disease that leads to progressive destruction of motor neurons in the brain and spinal cord brain no longer controls movement and the muscles weaken and atrophy difficulties w/speech, breathing, swallowing, eventually leading to full paralysis but does not affect intellectual ability, hearing, sight, other senses -20% of familial cases of ALS are associated with dominant mutations in the Cu/Zn superoxide dismutase gene, SOD1. The SOD1 gene encodes an antioxidant enzyme (SOD) that converts superoxide radicals to hydrogen peroxide and molecular oxygen
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