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Unformatted text preview: The NF-ATc–NF-ATn complex binds to the promoter of the interleukin 2 (IL-2) gene and initiates IL-2 production. Consequently, T cells do not produce IL-2, which is necessary for full T-cell activation. Tacrolimus (FK506) binds to FK506-binding protein (FKBP), forming a FK506–FKBP complex, which binds to and blocks CaN. The FK506–FKBP–CaN complex inhibits the activation of NF-ATc, thus preventing its entrance into the nucleus. Although the pre-drugs cyclosporine and FK506 bind to different target molecules, both drugs inhibit T-cell activation in the same fashion. Natural Products Drug Developments Food and Commodities Unnatural Products Biological Processes Organic Synthesis...
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This note was uploaded on 09/02/2009 for the course CHEM 151 taught by Professor Mccaferty during the Spring '08 term at Duke.
- Spring '08