nervous system development

nervous system development - The overall process of nervous...

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The overall process of nervous system development 1.The specification of neural cell (neuron or glial cell) identity; 2. The migration of neurons and outgrowth of axons to their targets 3. The formation of synapses with target cells; 4. The refinement of synaptic connections through the elimination of axon branches and cell death.
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Specification of cell identity in the nervous system Fig 10.2 Cross-section of a Drosophila early gastrula showing the location of the neurectoderm Neurectoderm: neurogenic zone Proneural clusters (proneural genes: achaete-scute ), ~30 neuroblast per hemisegment--- neurons; Ectoderm: glioblasts ( glial cells missing : gcm );
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Fig 10.3 Organization of invertebrate and vertebrate neuroepithlium into three columns of neural precursors Each column expresses a specific homeobox gene
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Fig 10.4 The role of Notch signaling in lateral inhibition in neural development in Drosophila One cell (random event) in the cluster starts to express Achaete protein at a higher level than the other cells--- neuroblast, others becoming epidermal cells
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Fig 10.5 The formation of neural cells from neuroblasts
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nervous system development - The overall process of nervous...

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