Lecture 2 - Lecture 2 Developmental Biology Feb 26 2008...

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Lecture 2 Developmental Biology Feb 26 2008 Readings in the textbook: p31-65
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Figure 1.25 The French flag model of pattern formation Morphogen 1. Act over a long distance. 2. Specify different cell fates at different concentrations. 3. It is usually difusable and forms a gradient.
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Figure 1.28 Cell division with asymetric distribution of cytoplasmic determinants.
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Fig.1.29 Stem Cells are cells that both renew themselves and give rise to differentiated cell types
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Useful Model Organisms for studying development Embryology Size of the egg and embryo Ability to develop in vitro Clarity of egg and embryo Genetics Ability to produce mutants Can reproduce in a short time with large numbers of progeny Biochemistry and Molecular Biology Can obtain large number of eggs and embryos to purify molecules A small genome to make screening of genes easier
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Mouse Advantages mammal, development close to human relatively short life cycle for a mammal (9 weeks) some in vitro development best system for mammalian genetics- knock out mutations or transgenic Genome sequenced Disadvantages small eggs (100um) and small embryos that make surgery, observation difficult, Develop in uterus
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Chicken Advantages eggs readily available embryonic development to adult in lab large eggs--observation and surgery throughout development (particularly later stages) is good large mass of material for later stages Disadvantages no genetics
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Frog ( Xenopus laevis ) Advantages large eggs (1-2mm), so observation and microsurgery are possible at early stages
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This note was uploaded on 09/03/2009 for the course BIO 503 taught by Professor Z.zyang during the Fall '09 term at Nanjing University.

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Lecture 2 - Lecture 2 Developmental Biology Feb 26 2008...

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