limb formation - Genes & Dev. 1999 Limb...

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Limb bud: Ectodermal epithelium + Mesenchyme :t f • “
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Ectopic FGF can induce ectopic limbs. .. Limb buds are induced by FGFs (fibroblast ) Ectopic i& &
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Molecular model for the initiation of the limb bud
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Lateral plate mesoderm Expresses FGF10 FGF8 in the AER (ectoderm) FGF10 thought to induce FGF8, and then FGF8 maintains FGF10
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Fgf - 10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless
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Unformatted text preview: Genes & Dev. 1999 Limb Identity: forelimb or hindlimb? Similar limb bud! The identity of the limb is determined by the expression of Tbx transcription factors Tbx-5 Tbx-4 h L & ! h L & ! ? Similar experiment? 3) Pattern formation a. proximal-distal axis b. anterio-posterior axis c. dorso-ventral axis Two signaling regions: 1)Polarizing region 1)Apical ectodermal ridge (AER) F bf ZPA i Zone o Polarizing Activity...
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limb formation - Genes & Dev. 1999 Limb...

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