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limb formation - Genes& Dev 1999 Limb Identity forelimb...

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Limb bud: Ectodermal epithelium ° + Mesenchyme :t fi • “
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*
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Ectopic FGF can induce ectopic limbs... Limb buds are induced by FGFs (fibroblast growth factors ° ° ° °° ° ° ° ± ) Ectopic i° °
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¤ : * specification ¤ : ² • “ ! ° ¤ : ² • “ ! ° ° i ° ¤ : ² • “ ! ¤ : ² ! lateral plate mesoderm Limb field
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Molecular model for the initiation of the limb bud
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Lateral plate mesoderm Expresses FGF10 FGF8 in the AER (ectoderm) FGF10 thought to induce FGF8, and then FGF8 maintains FGF10
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Fgf - 10 is required for both limb and lung development and exhibits striking
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Unformatted text preview: Genes & Dev. 1999 Limb Identity: forelimb or hindlimb? Similar limb bud! The identity of the limb is determined by the expression of Tbx transcription factors Tbx-5 Tbx-4 h L & • “ ! ± h L & • “ ! ? Similar experiment? 3) Pattern formation a. proximal-distal axis b. anterio-posterior axis c. dorso-ventral axis Two signaling regions: 1)Polarizing region 1)Apical ectodermal ridge (AER) F bf•“ ZPA i Zone o± Polarizing Activity...
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