MCDB428Lect04 - MCDB 428 Lecture 4: Friday January 11, 2008...

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Lecture 4: Friday January 11, 2008 Today’s Outline Lipid Bilayers Amphipathic nature Micelles, liposomes, and bilayers Lipid composition of Bilayers Phospholipids, sphingolipids and sterols Inner and outer leaflets of bilayers Proteins Present in Membranes Peripheral Lipid-modified Single-pass transmembrane Multiple-pass transmembrane Detergents Lipid Domains MCDB 428
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A Lipid Bilayer Define the cell and separate cellular process from outside environment Specify intracellular compartments such as nuclei, mitochondria, ER, Golgi, etc. ~5 nm thick, and in cells bilayer contains many proteins (up to ~50% of total mass)
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Lipids are Amphipathic Each lipid has both hydrophilic and hydrophobic ends that allow them to form stable structures that separate aqueous regions with a central nonpolar layer
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In Aqueous Environments, Lipids Form Three Different Types of Stable Structures
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Phosphoglycerides Fatty acid tails attached via ester linkages Glycerol-3-P Charged head group linked via phosphodiester bond hydrophobic hydrophilic Fatty acids can either be saturated (straight) or desaturated (kinked)
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MCDB428Lect04 - MCDB 428 Lecture 4: Friday January 11, 2008...

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