MCDB428Lect05 - MCDB 428 Lecture 5: Monday January 14, 2008...

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Lecture 5: Monday January 14, 2008 Today’s Outline Lipid Domains Membrane Permeability Membrane Transporter Proteins ATP pumps Channels Uniporters Symporters Antiporters Biochemical Characterization Detergent extraction Patch-Clamp method ATP Pump families P-type ATPase V-type ATPase F-type ATPase ABC transporters Na+/K+ Pump action Osmosis MCDB 428
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GM1 - a glycosphingolipid PLAP - alkaline phosphatase (GPI-anchored) TfR - transferrin receptor (integral membrane protein) Lipid Raft Hypothesis: Membrane Microdomains
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Black - Phosphatidylcholine Red - Sphyingomyelin Yellow - alkaline phosphatase Atomic Force Microscopy
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Permeability of Membranes to Small Molecules Gases with no charge can pass relatively easily Small hydrophobic molecules also pass through (many drugs and antibiotics fall into this class) Small polar molecules (e.g. H 2 O and glycerol) can pass through but not as efficiently Larger polar molecules and charged molecules are inpermeant and cannot traverse membrane without help
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This note was uploaded on 09/03/2009 for the course MCDB 428 taught by Professor Wang during the Winter '08 term at University of Michigan.

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MCDB428Lect05 - MCDB 428 Lecture 5: Monday January 14, 2008...

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