MCDB428lect06 - MCDB 428 Lecture 6 Wednesday Today's...

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Lecture 6: Wednesday January 16, 2008 Today’s Outline Membrane Transport Kinetics Km and Vmax Specificity GLUT1: Uniporter function Na+ Linked Glucose Symporter Function Epithelial Cell Glucose Transport Role of Na/K antiporter Na+ linked Glucose symporter Ion Channels Selectivity filter Ion hydration Membrane Potential Voltage-Gated Channels Na+ Channels K+ Channels Action Potential Synapse Function MCDB 428
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Membrane Transport Differs from Diffusion Transport is much faster, work like enzymes with K m Because there are limited number of proteins, transport can become saturated and display a V max Transporters display specificity D -glucose is transported, but not L -glucose even though rates of passive diffusion would be same
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GLUT1: Mechanism of Action K m is concentration at which half of GLUT1 in membrane are bound to glucose, this represents relative affinity of GLUT1 for glucose Binding of glucose, change to inward facing conformation, and release are completely
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This note was uploaded on 09/03/2009 for the course MCDB 428 taught by Professor Wang during the Winter '08 term at University of Michigan.

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MCDB428lect06 - MCDB 428 Lecture 6 Wednesday Today's...

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