Lecture 6: Wednesday January 16, 2008
Today’s Outline
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Membrane Potential revisited
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Protein Targeting
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Cytosolic ribosomes
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ER-associated ribosomes
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Signal-hypothesis
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ER signal peptide
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Presequence, transit peptide
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Nuclear Localization sequence
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ER targeting and protein translocation
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Elements of the translocon
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Co-translational translocation
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Post-translational translocation
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Type I-III proteins
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GPI-anchored proteins
MCDB 428
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