MCDB428lect08 - MCDB 428 Lecture 8: Wednesday January 23,...

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Lecture 8: Wednesday January 23, 2008 Today’s Outline Mitochondial Protein Import Presequence characteristics Elements of the translocation channels Outer Membrane targeting Translocation across inner membrane Chloroplastic Protein Import Elements of the translocation channels Outer Envelope targeting Translocation across the inner envelope Targeting to thylakoid membranes Nuclear Protein Translocation NLS characteristics Nuclear Import and Export Ran GTPase defining Cytoplasms and Nucleoplasm MCDB 428
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Targeting Domains Direct Newly-synthesized Proteins to Various Cell Compartments Signal Peptide: Directs proteins to ER, consists of 16-30 hydrophobic residues at amino-terminus Presequence: Directs proteins to Mitochondria, consists of amino-terminal, amphipathic alpha-helix Transit peptide: Directs proteins to Chloroplast, consists of 40-50 amino-terminal residues, no obvious structure NLS: Nuclear-Localization Sequence, generally one or more short, internal sequences rich in K or L residues
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-Organelles where this occurs: -ER -Mitochondria -Chloroplasts -Peroxisomes Protein Translocation Across Membranes: General Themes
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This note was uploaded on 09/03/2009 for the course MCDB 428 taught by Professor Wang during the Winter '08 term at University of Michigan.

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MCDB428lect08 - MCDB 428 Lecture 8: Wednesday January 23,...

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