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MCDB428lect09 - MCDB 428 Lecture 9 Friday Today's Outline...

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Lecture 9: Friday January 25, 2008 Today’s Outline N-linked Glycosylation Synthesis of the core precursor Inhibition by tunicamycin Trimming in the ER Surface Glycoproteins in Cell-Cell interaction Formation/Breakage of Disulfide Bonds Catalysis of disulfide bond formation PDI and Ero1 Protein Folding and Oligomerization Hemagglutinin (HA) function Role of disulfides in HA folding N-glycosyl trimming during HA folding Calnexin and glucosidase cycle during folding The unfolded protein response Defects in folding in disease MCDB 428
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Co-translational Translocation into ER What happens in ER <