Lecture 9: Friday January 25, 2008
Today’s Outline
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N-linked Glycosylation
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Synthesis of the core precursor
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Inhibition by tunicamycin
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Trimming in the ER
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Surface Glycoproteins in Cell-Cell interaction
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Formation/Breakage of Disulfide Bonds
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Catalysis of disulfide bond formation
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PDI and Ero1
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Protein Folding and Oligomerization
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Hemagglutinin (HA) function
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Role of disulfides in HA folding
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N-glycosyl trimming during HA folding
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Calnexin and glucosidase cycle during
folding
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The unfolded protein response
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Defects in folding in disease
MCDB 428
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Co-translational Translocation into ER
What happens in ER
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