MCDB428lect10 - MCDB 428 Lecture 10: Wednesday January 30,...

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Lecture 10: Wednesday January 30, 2008 Today’s Outline The Endomembrane Trafficking System Vesicle transport intermediates Topology of endomembrane compartments Vesicle budding and fusion The ER as an entry point Dynamics of ER compartments Sorting and Retention in the ER Bulk Flow versus Cargo Selection Models Sorting and retention signals in the ER Glycosyl chain modification in the Golgi Compartmentation of modification events in different Golgi cisternae Glycosyl chain modification steps Sorting in the TGN Secretion versus lysosomal targeting Mannose-6-phosphate modification Trafficking of the M-6-P receptors Endocytosis Membrane retrieval from the plasma membrane Early and late endosomes Lysosomes Phagocytosis and autophagy MCDB 428
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Trafficking Through The Endomembrane System Occurs via Vesicle Transport Intermediates Both membrane and cargo are recruited into vesicles and delivered to downstream compartments Unlike protein translocation, cargo does not cross a lipid bilayer Different classes of vesicles form from distinct organelles, and selectively fuse with their downstream target compartment
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Topological Relationships of Modern Endomembrane Compartments
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Budding and Fusion During Vesicle Transport Both soluble cargo and integral membrane proteins are sorted into budding vesicle that forms with help of cytosolic “coat” proteins
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This note was uploaded on 09/03/2009 for the course MCDB 428 taught by Professor Wang during the Winter '08 term at University of Michigan.

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MCDB428lect10 - MCDB 428 Lecture 10: Wednesday January 30,...

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