Actin filaments I - The cytoskeleton Types • Actin micro...

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Unformatted text preview: The cytoskeleton Types • Actin micro f laments • Intermediate f laments • Microtubules Functions • Cell motility • Movement of intracellular particles • Vesicle traf f cking • Chromosome • Regulation of cell shape Three major types of cytoskeletal fibers Microtubules: ¡- and ¢-tubulin ~ 25 nm in diameter Micro f laments: Actin, 5-9 nm in diameter; Intermediate f laments: 1. Lamins – found in nucleus 2. Keratin – epithelial cells 3. Desmin – muscle cells 4. Vimentin – mesenchymal cells ~ 10 nm in diameter Cytoskeletons in epithelial and migrating cells Actin filaments often form bundles associated with the plasma membrane Huge network Examples of microfilament-based structures Examples of microfilament-based structures Actin f laments- Highly conserved (375 aa) and high concentrations in the cell (0.1 – 0.5 mM). 1-5 % of all cellular protein (10% in muscle).- Three types (though nearly identical in sequence)- ¡-actin – three isoforms found in different muscle cells...
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This note was uploaded on 09/03/2009 for the course MCDB 428 taught by Professor Wang during the Winter '08 term at University of Michigan.

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Actin filaments I - The cytoskeleton Types • Actin micro...

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