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Actin filaments I - The cytoskeleton Types Actin...

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The cytoskeleton Types Actin microfilaments Intermediate filaments Microtubules Functions Cell motility Movement of intracellular particles Vesicle trafficking Chromosome Regulation of cell shape
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Three major types of cytoskeletal fibers Microtubules: α - and β -tubulin ~ 25 nm in diameter Microfilaments: Actin, 5-9 nm in diameter; Intermediate filaments: 1. Lamins – found in nucleus 2. Keratin – epithelial cells 3. Desmin – muscle cells 4. Vimentin – mesenchymal cells ~ 10 nm in diameter
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Cytoskeletons in epithelial and migrating cells Actin filaments often form bundles associated with the plasma membrane Huge network
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Examples of microfilament-based structures
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Examples of microfilament-based structures
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Actin filaments - Highly conserved (375 aa) and high concentrations in the cell (0.1 – 0.5 mM). 1-5 % of all cellular protein (10% in muscle). - Three types (though nearly identical in sequence) - α -actin – three isoforms found in different muscle cells - β
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