Apoptosis - Apoptosis apo = from, off, away ptosis = act of...

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apo = from, off, away ptosis = act of falling Apoptosis Two Major Types of Cell Death • Apoptosis: Programmed cell death by activating an intracellular death program. A genetically regulated process to destroy a cell itself by a serial well defined biochemical and morphological changes. • Necrosis: accidental cell death without order caused by injury, radiation, chemicals or lack of nutrition. These dead cells do not send signals to phagocytes and thus often causes inflammation.
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Roles of apoptosis To remove unwanted cells or structures
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C. elegans as a Model to Study Cell Death 131 of 1090 cells die during development 959 cells in adult C. elegans is a model system to study apoptosis Ced-1: No phagocytsosis of apoptotic cells Ced-1/ced-3: No apoptotic cells To remove unwanted cells
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Processes Involving Apoptosis Sculpting tissue Certain tissues need to eliminate cells to sculpt the tissue. Cell death marker Embryonic mouse paw Wood W et al Development 2000 Alberts Fig. 17-35 Deleting Unwanted Structures Jacobson et al Cell vol 88;1997 Tadpole Adult frog
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The survival of motor neurons depends on the size of the muscle they target Normally ~50% neurons survive during development, the rest go apoptosis Growth factors are important for cell survival
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Distinguishing Features of Apoptosis Cytoplasmic condensation (cell shrinkage) Cytoskeleton collapse Nuclear pyknosis; Chromatin condensation; DNA
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Apoptosis - Apoptosis apo = from, off, away ptosis = act of...

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