Apoptosis - Apoptosis apo = from, off, away ptosis = act of...

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apo = from, off, away ptosis = act of falling Apoptosis
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Two Major Types of Cell Death • Apoptosis: Programmed cell death by activating an intracellular death program. A genetically regulated process to destroy a cell itself by a serial well defined biochemical and morphological changes. • Necrosis: accidental cell death without order caused by injury, radiation, chemicals or lack of nutrition. These dead cells do not send signals to phagocytes and thus often causes inflammation.
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Roles of apoptosis To remove unwanted cells or structures
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C. elegans as a Model to Study Cell Death 131 of 1090 cells die during development 959 cells in adult
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C . e le g a ns  is  a  m o de l s ys te m  to  s tudy a po pto s is Ced-1: No phagocytsosis of apoptotic cells Ced-1/ced-3: No apoptotic cells To remove unwanted cells
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Processes Involving Apoptosis Sculpting tissue C e rta in tis s ue s  ne e d to  e lim ina te  c e lls  to  s c ulpt the  tis s ue .  Cell death marker Embryonic mouse paw Wood W et al Development 2000 Alberts Fig. 17-35
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Deleting Unwanted Structures  Jacobson et al Cell vol 88;1997 Tadpole Adult frog
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The  s urviva l o f m o to r  ne uro ns  de pe nds  o n the   s ize  o f the  m us c le  the y  ta rg e t  Normally ~50% neurons survive during development, the rest go apoptosis
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G ro wth fa c to rs  a re  im po rta nt fo r c e ll s urviva l
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Dis ting uis hing  Fe a ture s  o f Apo pto s is Cytoplasmic condensation (cell shrinkage) Cytoskeleton collapse
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This note was uploaded on 09/03/2009 for the course MCDB 428 taught by Professor Wang during the Winter '08 term at University of Michigan.

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Apoptosis - Apoptosis apo = from, off, away ptosis = act of...

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