Cancer - MCDB428 Final Exam When: Wednesday, April 23rb...

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MCDB428 Final Exam When: Wednesday, April 23rb from 4 - 6 p.m. Where: Nat. Sci. Aud We will have a review section on Wednesday, April 16th from 9-10 a.m. in this lecture room. I will be happy to answer your questions during this time.
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I. Intro to cancer I. The genetic basis of cancer I. Targeted anti-cancer therapeutics Cancer
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I. Intro to cancer What is Cancer? A m a s s  o f c e lls  (e .g . a tum o r) that  1) pro life rate  in de fia nc e  o f the  no rm a l re s traints  o n c e ll divis io n; 2) inva de  a nd c o lo nize   te rrito rie s  re s e rve d fo r o the r c e lls . C a nc e r is  the  #1  c a us e  o f de a th (~20% ). Process of cancer formation = Tumorigenesis  (Fo rm a tio n o r pro duc tio n o f tum o rs ); = Carcinogenesis  (the  c re a tio n o f c a nc e r);  = Oncogenesis  (a  tum o r fo rm ing  pro c e s s )
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Carcinomas C a nc e r de rive d fro m  e pithe lia l c e lls . Sarcomas C a nc e r a ris e n fro m  c o nne c tive  tis s ue  o r  m us c le  c e lls . Leukemia C a nc e r de rive d fro m  he m o po ie tic  (b lo o d)  c e lls . Types of cancer Ac ute  m ye lo g e no us  le uke m ia Me la no m a  tum o r
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Six fundamental cellular properties are altered during tumorigenesis Telomerase VEGF 1 2 3 5 4 6 Apoptosis Cell survival Checkpoint control Tumor suppressor genes Oncogenes Metastasis Liver Cancer (from lung) Cell adhesion
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Cancer development: a multi-step process Most cancers derive from a single abnormal cell Primary tumor:  A tumor that is at the original site where it first arose. Secondary tumor:  A tumor has spread from the original site where it first arose. Cancer result from somatic mutation C anc e r c e lls  have  a b no rm ality in the ir DNA s e q ue nc e .  Carcinogens  tha t c a us e   DNA m utag e ne s is  als o  c a us e  c a rc ino g e ne s is . The  s us c e ptib ility to  c anc e r c an  b e  fa m ily re la te d a nd inhe rite d. A single mutation is not enough to cause cancer--Cancer is a multi-step process An e s tim ate d 10 16  cell divisions take place in a normal human body. DNA mutation rate is about  10 -6 . This means each of us have 10 10  separate occasions of DNA mutations. Cancer incidence is age dependent The  inc ide nc e  o f c a nc e r ris e s  s te e ply a s  a  func tio n o f ag e . Cancer development requires mutations in many genes This  c a n be  a c c um ulate d in m any ye a rs  with m o re  tha n 10 g e ne s .
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Incidence of human cancer increases as a function of age Lodish Fig. 25-7 All kinds of cancer
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Survival of mice carrying  mutations in Ras, myc or  both Cancer development requires mutations in many genes
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Focus formation assay in NIH-3T3s: Assays ability of cells to lose contact dependence Vector Control Oncogene: v-Src v-Fos Activated-Ras
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The genetic basis of colorectal cancer development Lodish Fig. 25-9 APC: adenomatous  polyposis coli DCC: Deleted in Colon Carcinoma
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This note was uploaded on 09/03/2009 for the course MCDB 428 taught by Professor Wang during the Winter '08 term at University of Michigan.

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Cancer - MCDB428 Final Exam When: Wednesday, April 23rb...

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