Cell adhesion note - CELL ADHESION(Lodish page 801-819 I...

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CELL ADHESION (Lodish page 801-819) I. Cells in multicellular animals organized into distinct tissues; cells need to adhere in tissues; tissues need to be supported and kept separate from one another. This is through cell adhesion and ECM (Lodish Fig. 19-1): A. Cell adhesion molecules: cell surface proteins that bind cells to other cells (e.g., cadherins) or matrix components (e.g., integrins) B. Extracellular matrix: secreted network of proteins and carbohydrates C. Cell junctions: structures for cell-cell or cell-matrix adhesion; clusters of adhesion molecules and cytoskeleton attachments D. These interactions also play a role in many biological processes, including cell survival, proliferation, differentiation, and migration. II. Cell adhesion molecules A. Velcro effect: multiple receptors binding to multiple ligands (on opposite cell or matrix) more abundant than typical receptors; relatively low affinity; strength comes from numbers of interactions, strength also comes from linkages with cytoskeleton. B. 4 CLASSES OF ADHESION MOLECULES (Lodish Fig. 19-2): 1. Cadherins: single pass integral membrane protein; calcium dependent; homodimer, 40 types, mainly E, P, and N (E-cadherins, epithelial sheets); homophilic cell-cell interactions;
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This note was uploaded on 09/03/2009 for the course MCDB 428 taught by Professor Wang during the Winter '08 term at University of Michigan.

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Cell adhesion note - CELL ADHESION(Lodish page 801-819 I...

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