Cell cycle II - MPF substrates Nuclear lamins: nuclear...

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MPF substrates Nuclear lamins: nuclear envelope disassembly Proteins involved in chromosome condensation, spindle assembly, chromosome alignment (e.g. APC, Histone, nuclear pore proteins, Golgi structural proteins, etc.) The nuclear lamina and its depolymerization Lodish Fig. 20-16
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Disassembly of the nuclear lamina Phosphorylation of nuclear envelope proteins by MPF
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Post-mitotic nuclear envelope reassembly Decondensing chromosome P97 mediated homotypic vesicle fusion telophase ATP analog-dependent cdk mutant
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Model of cohesin linkage of daughter chromosomes Regulation of cohesin cleavage SMC proteins: structural maintenance of chromosomes proteins
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Localization of PP2A at the centromere APC/C is a Ubiquitin ligase MPF = mitotic cyclin (cyclin B) + mitotic cdk1 (cdc2) APC/C: anaphase- promoting complex /cyclosome (APC/C) Active only in late anaphase Regulated by cdh1 APC/C substrates: - Cyclin B (mitotic) (Cdh1) - securin (Cdc20)
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CYCLIN B1 ARG -THR-ALA- LEU - GLY -ASP- ILE - GLY -ASN Cyclin destruction box Polyubiquitination on lysine (Cdh1/APC/C) Target for destruction by proteasome Entry into mitosis requires accumulation of cyclin B Exit from mitosis requires degradation of cyclin B
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This note was uploaded on 09/03/2009 for the course MCDB 428 taught by Professor Wang during the Winter '08 term at University of Michigan.

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Cell cycle II - MPF substrates Nuclear lamins: nuclear...

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