Cell cycle II - MPF substrates Nuclear lamins nuclear envelope disassembly Proteins involved in chromosome condensation spindle assembly chromosome

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MPF substrates Nuclear lamins: nuclear envelope disassembly Proteins involved in chromosome condensation, spindle assembly, chromosome alignment (e.g. APC, Histone, nuclear pore proteins, Golgi structural proteins, etc.)
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The nuclear lamina and its depolymerization Lodish Fig. 20-16
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Disassembly of the nuclear lamina
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Phosphorylation of nuclear envelope proteins by MPF
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Post-mitotic nuclear envelope reassembly Decondensing chromosome P97 mediated homotypic vesicle fusion telophase
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ATP analog-dependent cdk mutant
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Model of cohesin linkage of daughter chromosomes
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Regulation of cohesin cleavage SMC proteins: structural maintenance of chromosomes proteins
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Localization of PP2A at the centromere
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APC/C is a Ubiquitin ligase MPF = mitotic cyclin (cyclin B) + mitotic cdk1 (cdc2) APC/C: anaphase- promoting complex /cyclosome (APC/C) Active only in late anaphase Regulated by cdh1 APC/C substrates: - Cyclin B (mitotic) (Cdh1) - securin (Cdc20)
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CYCLIN B1    ARG -THR-ALA- LEU - GLY -ASP- ILE - GLY -ASN Cyclin destruction box Polyubiquitination on lysine (Cdh1/APC/C) Target for destruction by proteasome Entry into mitosis requires accumulation of cyclin B Exit from mitosis requires degradation of cyclin B The destruction box of cyclins
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This note was uploaded on 09/03/2009 for the course MCDB 428 taught by Professor Wang during the Winter '08 term at University of Michigan.

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Cell cycle II - MPF substrates Nuclear lamins nuclear envelope disassembly Proteins involved in chromosome condensation spindle assembly chromosome

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