Extracellular matrix

Extracellular matrix - the length and chemical...

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Tight junctions  prevent passage of  large molecules
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Tight junction, polarity and transepithelial transport
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Gap junctions
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Gap junction Hexagonal cylindrical particles that compose pores connecting the cytoplasms of adjacent cells. Pore size: 1.2 nm in diameter Composed of connexins (vertebrate, 12 homo- or hetero- connexins per channel, 6 per cell), innexins (invertebrate), or pannexins (both) Allows molecules smaller than 1.2 kD to pass (ions, vitamins, signaling molecules, small peptides, etc.) Permeability can be regulated by pH, Ca2+ concentration and connexin phosphorylation. In heart, for example, Ca2+ diffusion through gap junctions is important for coordinate contraction Mutations in the connexin genes cause 8 human diseases, such as neurosensory deafness.
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Gap junctions
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Extracellular Matrix (ECM)
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Basal lamina separates epithelial cells and connective tissue
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Proteins in the basal lamina
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Laminin
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The collagen triple helix Different collagens are distinguished by
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Unformatted text preview: the length and chemical modifications of their a chains and by the presence of segments that interrupt of flank their triple-helical regions Assembly of type IV collagen Type IV collagen network Biosynthesis of fibrillar collagen Interactions of fibrous collagens with nonfibrous collagens GAGs (glycosaminoglycans) O-linked polysaccharides O-linked polysaccharides The GAG sequence that regulates anti-thrombin Proteoglycan aggregate from cartilage Fibronectin The RGD binding sequence of fibronectin The RGD sequence of fibronectin and cell adhesion Fibronectin, integrins and the cytoskeleton ( actin ) Fibronectin, integrins and the cytoskeleton Integrins cluster into adhesive structures in fibroblasts Model for integrin activation Dystrophin glycoprotein complex in skeletal muscle cells Cell-cell adhesion in leukocyte extravasation...
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This note was uploaded on 09/03/2009 for the course MCDB 428 taught by Professor Wang during the Winter '08 term at University of Michigan.

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Extracellular matrix - the length and chemical...

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