Extracellular matrix note

Extracellular matrix note - EXTRACELLULAR MATRIX (Lodish...

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EXTRACELLULAR MATRIX (Lodish Page 820-839) I. The basal lamina (Lodish Fig. 19-19) A. Dense specialized ECM, underlies epithelial sheets (~60-120 nm thick), surrounds endothelial tubes (capillaries); surrounds and connects muscle, fat and Schwann cells B. Separates the epithelial cells and cells in the connective tissue C. Functions of basal lamina: 1. Filter (capillary, kidney, intestine) 2. Barrier to cell movement 3. Scaffolding for regeneration 4. Highways for migration D. Structure of basal lamina (Lodish Fig. 19-20): 1. Type IV collagen--more flexible than fibrillar collagens, assemble into sheet like, multilayered network 2. Perlecan = heparan sulfate proteoglycan 3. Laminin--3 polypeptides with multiple binding domains (Lodish Fig. 19-21) a. Binds cells to basal laminae b. c. Type IV collagen forms the basic structure; laminin (cross shaped) weaves in and out connecting everything to the cell and everything else II. COLLAGENS (Lodish Fig. 19-22) A. Structure: abundant ~25% of mass; fibrous; triple helix. Most collagen secreted by fibroblasts
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Extracellular matrix note - EXTRACELLULAR MATRIX (Lodish...

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