Intermediate filaments - Intermediate filaments assembly...

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Intermediate Filaments - Named because of their thickness (10 nm), which is between actin microfilaments (7 nm) and microtubules (25 nm). - Found in animal cells but not in plant and fungi (bacteria IF). - In epidermal cells and the axons of nerve cells, IFs are 10x more abundant than microfilaments or microtubules. - Different from the other two classes of filaments More stable • Form ! -helical rods Subunits don’t bind NTPs (ATP/GTP) No role in cell motility (structural role only) No IF associated motor proteins found. PtK2 cell: keratin and lamin Karatin and lamin intermediate filaments in a PtK2 cell PtK2 cell: kidney cell line from an adult male rat kangaroo
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Intermediate filaments assembly
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Unformatted text preview: Intermediate filaments assembly Intermediate filaments assembly Intermediate filaments assembly heterodimers (acid/basic), found in “hard” tissues and epithelia The intermediate filaments are dynamic Cell cycle regulated nuclear envelope breakdown and reformation The nuclear lamina The nuclear lamina and its depolymerization Lodish Fig. 20-16 MT , IF and short connecting fibers (plectrin) IFAPs cross links the intermediate filaments & microtubules Microtubules and intermediate filaments in a neuronal axon Lodish Fig. 18-2 Blistering of the skin caused by a mutant karatin gene Cdc42 regulates microfilaments and microtubules in cell micration...
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