Lipid transport - Intracellular Lipid Transport What are...

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Intracellular Lipid Transport What are the major lipids in the membrane? Where are they made? How are they transported inside or outside of the cell? How does the cell regulate the lipid levels in the membranes? What will happen if any of above is out of order? Lipid is the major component of the biomembrane
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1) Lipids are insoluble in water, therefore transport proteins are needed 2) Generally speaking, most membrane lipids are synthesized on the cytoplasmic surface of the ER, and some are modified in the Golgi; 3) Flippases: flip lipid from the cytoplasmic surface into the luminal surface of the ER; 4) Lipoproteins, or lipid-binding proteins, mediate lipid transport in the cytosol and outside of the cell; 5) Membranes: involves in lipid transport between membrane organelles as well as the uptake of lipoproteins at the PM (LDL and HDL); 6) Transport across the PM is mediated by transporters; 7) Lipid synthesis is regulated by SREBPs at the transcription level. Major membrane lipids - Phospholipids Phosphatidylcholine (PC) Phosphatidylserine (PS) Phosphatidylethanolamine (PE) Sphingomyelin (SM) - Cholesterol - Glycolipids Ceramide is synthesized on the
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This note was uploaded on 09/03/2009 for the course MCDB 428 taught by Professor Wang during the Winter '08 term at University of Michigan.

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Lipid transport - Intracellular Lipid Transport What are...

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