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Microtubules Ia - Microtubules Three major types of...

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Microtubules
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Three major types of cytoskeletal fibers Microtubules: α - and β -tubulin ~ 25 nm in diameter Microfilament: Actin, 5-9 nm in diameter; Intermediate filament 1. Lamins – found in nucleus 2. Keratin – epithelial cells 3. Desmin – muscle cells 4. Vimentin – mesenchymal cells ~ 10 nm in diameter
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The microtubules in interphase and mitotic cells
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Isolated mitotic spindle
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Microtubules and intermediate filaments in a neuronal axon
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Cilia in a rabbit oviduct and the beat of a cilium Lodish Fig. 18-2 Alberts Fig. 16-76
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Structure of tubulin dimers
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Assembly of microtubules
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Singlet, doublet, and triplet microtubules
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The microtubule organization center (MTOC)
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Microtubule (green)  and  MTOC (red)  in tissue culture cells
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The Centrosome and microtubule organization
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Centrosome: the microtubule organization center (MTOC)
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Centrosome: the microtubule organization center (MTOC)
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The  γ -tubulin ring complex ( γ -TuRC) nucleates MT assembly
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Microtubule dynamics
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Microtubule dynamics
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Microtubule treadmilling GTP
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The polarity of tubulin assembly
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Dynamic instability of microtubules in vitro
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