Regulated protein degradation

Regulated protein degradation - Regulated protein...

Info icon This preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon
Regulated protein degradation - Protein degradation in the lysosomes - Endocytosis - Autophagy - Phagocytosis - Protein degradation by the proteasomes - Ubiqutin and ubiquitination (ubiquitylation) - Proteasome
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Hershko, Ciechanover & Rose: 2004 Nobel prize in Chemistry Rabbit reticulocytes (without lysosomes) can degrade abnormal Hemoglobin Develop in vitro proteolysis system ATP dependent proteolysis Fractionate reticulocyte system Active principle in fraction 1 = ubiquitin Ubiquitin is a heat stable, ubiquitous (eukaryotic cells), 76 amino acid, covalently attached to substrates Historical perspective of ubiquitination
Image of page 2
The structure of ubiquitin Figure 6-92a Molecular Biology of the Cell (© Garland Science 2008)
Image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Ubiquitination and deubiquitination Figure 6-92a Molecular Biology of the Cell (© Garland Science 2008) Ubiquitination Deubiquitination
Image of page 4
Figure 6-93 Molecular Biology of the Cell (© Garland Science 2008) Mono- and poly- ubiquitination
Image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
QuickTime and a TIFF (Uncompressed) decompressor are needed to see this picture.
Image of page 6
Image of page 7
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern