Regulated protein degradation

Regulated protein degradation - Regulated protein...

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Regulated protein degradation - Protein degradation in the lysosomes - Endocytosis - Autophagy - Phagocytosis - Protein degradation by the proteasomes - Ubiqutin and ubiquitination (ubiquitylation) - Proteasome
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Rabbit reticulocytes (without lysosomes) can degrade abnormal Hemoglobin Develop in vitro proteolysis system ATP dependent proteolysis Fractionate reticulocyte system Active principle in fraction 1 = ubiquitin Ubiquitin is a heat stable, ubiquitous (eukaryotic cells), 76 amino acid, covalently attached to substrates Historical perspective of ubiquitination
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The structure of ubiquitin Figure 6-92a Molecular Biology of the Cell (© Garland Science 2008)
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Ubiquitination and deubiquitination Figure 6-92a Molecular Biology of the Cell (© Garland Science 2008) Ubiquitination Deubiquitination
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Figure 6-93 Molecular Biology of the Cell (© Garland Science 2008) Mono- and poly- ubiquitination
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QuickTime and a TIFF (Uncompressed) decompressor are needed to see this picture. Hicke et al. ‘05 NRMCB 6:610
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Regulated protein degradation - Regulated protein...

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