Signaling I - Signaling Signaling molecules and receptors...

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Signaling Signaling molecules and receptors 3/26 G-protein coupled receptors 3/26, 3/28 Second messengers 3/28 TGF ± signaling 3/31 Cytokine receptors and the JAK/STAT pathway 3/31 Receptor tyrosine kinases 3/31 The MAP kinase pathway 4/2 Phosphatidylinositol signaling 4/2 Other pathways 4/2 1. We will focus on pathways across the PM - G-protein coupled receptors - Enzyme coupled receptors - channel regulation - nuclear receptors 2. Generation of secondary messengers - cAMP, cGMP, DAG, IP3, Ca2+ 3. Effects through effectors--the outcome 4. Understand the major signaling pathways in the cell Four goals on study of signaling
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Cell signaling initiates a cascade of intracellular events 2nd messenger Protein phosphorylation & activation Amplification Secretion Feedback Why signal to your neighbor?
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Modes of signaling Small hydrophobic signaling molecules: steroid hormones, thyroid hormones Diffuse through the plasma membrane to the nucleus Activated nuclear receptors regulates gene transcription.
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