Signaling II - Human rod cell Rhodopsin and cGMP-gated Na+...

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Human rod cell Rhodopsin and cGMP-gated Na+ channels Light triggered conformational change of Rhodopsin
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Molecular biology of vision cGMP phosphodiesterase (PDE) G ± t Structure model of rhdopsin and Gt protein
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Visual Adaptation Activation and inhibition of adenylyl cyclase ACTH: Adrenocorticotropic hormone; PGE1: Prostaglandin E1
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Adenylyl cyclase Agonist : synthetic analog of natural ligand that binds the receptor and stimulates its activity; Antagonist : synthetic analog of natural ligand that binds the receptor and inhibits its activity.
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The PKA pathway CRE: cAMP response element CREB: CRE-binding protein CBP: CREB-binding protein Activation of cAMP
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Activation of PKA by cAMP Synthesis and degradation of glycogen
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Regulation of glycogen metabolism by cAMP More cAMP, more metabolism, more exciting
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Amplification of a signal downstream a surface receptor How to inactivate GPCR signaling afterwards 1. Reduced af f nity of ligand for receptor upon G-protein activation 2. GTPase activity of G-proteins and regulation by Regulators of G-
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Signaling II - Human rod cell Rhodopsin and cGMP-gated Na+...

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