Signaling II - Human rod cell Rhodopsin and cGMP-gated Na...

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Human rod cell Rhodopsin and cGMP-gated Na+ channels
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Light triggered conformational change of Rhodopsin
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Molecular biology of vision cGMP phosphodiesterase (PDE) G α t
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Structure model of rhdopsin and Gt protein
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Visual Adaptation
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Activation and inhibition of adenylyl cyclase ACTH: Adrenocorticotropic hormone; PGE1: Prostaglandin E1
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Adenylyl cyclase
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Agonist : s ynthe tic  analo g  o f natural lig and that binds  the   re c e pto r and  stimulates  its  ac tivity; Antagonist : s ynthe tic  analo g  o f natural lig and that binds  the   re c e pto r and  inhibits  its  ac tivity.
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The  PKA pathway CRE: cAMP response element CREB: CRE-binding protein CBP: CREB-binding protein
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Ac tivatio n o f c AMP
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Ac tivatio n o f PKA by c AMP
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S ynthe s is  and de g radatio n o f g lyc o g e n
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Re g ulatio n o f g lyc o g e n m e tabo lis m  by c AMP
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More cAMP, more metabolism, more exciting
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Am plific atio n o f a s ig nal do wns tre am  a s urfac e  re c e pto r
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