Signaling II - Human rod cell Rhodopsin and cGMP-gated Na+...

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Human rod cell Rhodopsin and cGMP-gated Na+ channels
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Light triggered conformational change of Rhodopsin
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Molecular biology of vision cGMP phosphodiesterase (PDE) G α t
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Structure model of rhdopsin and Gt protein
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Visual Adaptation
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Activation and inhibition of adenylyl cyclase ACTH: Adrenocorticotropic hormone; PGE1: Prostaglandin E1
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Adenylyl cyclase
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Agonist : s ynthe tic  a na lo g  o f na tura l lig a nd tha t b inds  the   re c e pto r a nd  stimulates  its  a c tivity; Antagonist : s ynthe tic  a na lo g  o f na tura l lig a nd tha t b inds  the   re c e pto r a nd  inhibits  its  a c tivity.
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The  PKA pa thwa y CRE: cAMP response element CREB: CRE-binding protein CBP: CREB-binding protein
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Ac tiva tio n o f c AMP
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Ac tiva tio n o f PKA b y c AMP
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S ynthe s is  a nd de g ra da tio n o f g lyc o g e n
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Re g ula tio n o f g lyc o g e n m e ta b o lis m  b y c AMP
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Signaling II - Human rod cell Rhodopsin and cGMP-gated Na+...

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