Signaling III _Chap 16_

Signaling III _Chap 16_ - Insulin secretion in response to...

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Insulin secretion in response to a rise in blood glucose Protein phosphorylation plays a critical role in signaling
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Protein kinases in signal transduction • Serine/threonine kinases • Tyrosine kinases Protein phosphatases • Serine/threonine phosphatases PP1, PP2A, PP2B (Calcineurin), PP2C, PP4, PP5 • Tyrosine phosphatases (PTPs) Eight major receptor mediated signaling pathways
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Lodish Fig. 16-1 Eight major receptor mediated signaling pathways Formation of TGF ± signaling molecules LTBP: Latent TGF ± - binding protein Interchain disulfide bonds Intrachain disulfide bonds Latent can mean "hidden", "presently inactive" or "potentially existing but not yet realized".
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Structure of TGF ± signaling molecules The TGF ± signaling pathway TGF ± signaling often blocks cell proliferation so factors that block its activity can function as oncogenes
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Termination of the TGF ± signaling pathway Lodish Fig. 16-1 Eight major receptor mediated signaling pathways
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Erythropoietin and red blood cell formation CFU-E: colony- forming unit- erythroid
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Erythropoietin receptor activation and downstream cascades EpoR and JAK2 knockout mice are lethal
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Gene structure and activation of cytokine receptors The structure of the SH2 domain
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Activation of JAK/STAT proteins Structure of JAK proteins
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• PDZ domain – binds specific C-terminal sequences • SH3 domain (Src homology 3 domain) – binds proline-rich sequence (Lodish Fig. 16-23) • SH2 domain (Src homology 2 domain) – binds phospho-tyrosine sequences
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Signaling III _Chap 16_ - Insulin secretion in response to...

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