Lecture 28 Sex Linkage Errors&Exceptions Slides

Lecture 28 Sex Linkage Errors&Exceptions Slides -...

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Unformatted text preview: Part I: Sex-linked genes Part 2: Errors in inheritance Part 3: Exceptions to Mendels laws Chapter 15 6 th ed.: 271-272,276-282 7 th ed.: 276,282-285,287 8 th ed.: 288-292,297-302 Autosomes = chromosomes in homologous pairs Sex chromosomes : not always in homologous pairs Humans & flies: XX = female (hom. pair) XY = male All eggs; X Sperm: 1/2 X; 1/2 Y Other species: different sex chroms Few genes on Y chromosome Genes on X chromo- some are sex-linked males are hemizygous Drosophila eye color gene is sex-linked wild type = red eye mutant = white eye red: (dominant) w+ white: (recessive) w Drosophila eye color studied by Morgan white-eye x red-eye all red-eyed P F1 F2 3:1 red:white At first, results look like Mendels monohybrid cross F2 Total: 3:1 red:white But: results are different for males and females in F2 : 1:1 red: white : all red Explanation: gene is sex-linked P generation : is w+ w+, so all eggs are w+ (mutant) is w -, so sperm are half w and half - x chrom. y chrom. F1 generation : all are w+ w all are w+ - eggs P F1 (F1; all red-eyed) F2 generation : are half w+ w+ and half w+ w are half w+ - and half w - F1 F2 eggs Sex-linked disorders in humans-color blindness -hemophilia -Duchenne muscular dystrophy -genes on X chrom....
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This note was uploaded on 09/04/2009 for the course SBU 101 taught by Professor Debag during the Spring '09 term at SUNY Stony Brook.

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Lecture 28 Sex Linkage Errors&Exceptions Slides -...

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